- PII
- 10.31857/S0044453723050187-1
- DOI
- 10.31857/S0044453723050187
- Publication type
- Status
- Published
- Authors
- Volume/ Edition
- Volume 97 / Issue number 5
- Pages
- 685-692
- Abstract
- Negative ion mass spectrometry is used to study processes of resonant electron attachment by 5‑methyluridine and 3'-deoxythymidine nucleoside molecules in the electron 0–14 eV range of energies. It is established that they are similar to those in nucleosides studied earlier (uridine, deoxyuridine, thymidine). The main channels of the fragmentation of molecular ions are revealed, and the absolute cross sections for the formation of fragment ions are determined. It is found that the intensity of the breaking the glycosidic bond in 3'-deoxythymidine in the region of low energies is two and a half orders of magnitude below the one in stavudine, testifying to the prospect of replacing the antiretroviral drug stavudine with 3'-deoxythymidine if radiation therapy is required for oncological diseases contracted as complications of HIV.
- Keywords
- резонансный захват электронов отрицательные ионы нуклеозиды 5-метил-уридин 3'-дезокситимидин антиретровирусные препараты
- Date of publication
- 12.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 10
References
- 1. Gorfinkiel J.D., Ptasinska S. // J. Phys. B. 2017. V. 50. P. 182001.https://doi.org/10.1088/1361-6455/aa8572
- 2. Cobut V., Frongillo Y., Patau J.P. et al. // Radiat. Phys. Chem. 1998. V. 51. P. 229. https://doi.org/10.1016/S0969-806X (97)00096-0
- 3. Jian-Xing X. // JSM Cell Dev Biol. 2015. V. 3. P. 1014.
- 4. Boudaïffa B., Cloutier P., Hunting D. et al. // Science. 2000. V. 287. P. 1658. https://doi.org/10.1126/science.287.5458.1658
- 5. Aflatooni K., Gallup G.A., Burrow P.D. // J. Phys. Chem. 1998. V. 102. P. 6205.https://doi.org/10.1021/jp980865n
- 6. Denifl S., Ptasińska S., Hanel G. et al. // J. Chem. Phys. 2004. V. 120. P. 6557.https://doi.org/10.1063/1.1649724
- 7. Denifl S., Ptasińska S., Probst M. et al. // J. Phys. Chem A. 2004. V. 108. P. 6562. https://doi.org/10.1021/jp049394x
- 8. Gohlke S., Abdoul-Carime H., Illenberger E. // Chem. Phys. Lett. 2003. V. 380. P. 595.https://doi.org/10.1016/j.cplett.2003.09.013
- 9. Ptasińska S., Denifl S., Mróz B. et al. // J. Chem. Phys. 2005. V. 123. P. 124302. https://doi.org/10.1063/1.2035592
- 10. Huber D., Beikircher M., Denifl S. et al. // Ibid. 2006. V. 125. P. 084304.https://doi.org/10.1063/1.2336775
- 11. Hanel G., Gstir B., Denifl S. et al. // Phys. Rev. Lett. 2003 V. 90. P. 188104. https://doi.org/10.1103/PhysRevLett.90.188104
- 12. Ptasińska S., Denifl S., Scheier P., Märk T.D. // J. Chem. Phys. 2004. V. 120. P. 8505. https://doi.org/10.1063/1.1690231
- 13. Bald I., Kopyra J., Illenberger E. // Angew. Chem. Int. Ed. 2006. V. 45. P. 4851.https://doi.org/10.1002/anie.200600303
- 14. Sulzer P., Ptasinska S., Zappa F. et al. // J. Chem. Phys. 2006. V. 125. P. 044304.https://doi.org/10.1063/1.2222370
- 15. König C., Kopyra J., Bald I., Illenberger E. et al. // Phys. Rev. Lett. 2006. V. 97. P. 018105.https://doi.org/10.1103/PhysRevLett.97.018105
- 16. Муфтахов М.В., Щукин П.В. // Масс-спектрометрия. 2013. Т. 10. № 1. С. 39.https://doi.org/10.1134/S1061934813140086
- 17. Muftakhov M.V., Shchukin P.V. // Rapid Commun. Mass Spectrom. 2019. V. 33. P. 482.https://doi.org/10.1002/rcm.8354
- 18. Muftakhov M.V., Shchukin P.V., Khatymov R.V. // Radiat. Phys. Chem. 2021. V. 184. P. 109464. https://doi.org/10.1016/j.radphyschem.2021.109464
- 19. Мазунов В.А., Щукин П.В., Хатымов Р.В., Муфтахов М.В. // Масс-спектрометрия. 2006. Т. 3. № 1. С. 11.
- 20. Muftakhov M.V., Vasil’ev Yu.V., Mazunov V.A. // Rapid Commun. Mass Spectrom. 1999. V. 13. P. 1104https://doi.org/10.1002/ (SICI)1097-0231(19990630)13: 123.0.CO;2-C
- 21. Khatymov R.V., Muftakhov M.V., Mazunov V.A. // Rapid Commun. Mass Spectrom. 2003. V. 17. P. 2327.https://doi.org/10.1002/rcm.1197
- 22. Edelson D., Griffiths J. E., McAffe K.B. // J. Chem. Phys. 1962. V. 73. P. 919.
- 23. Ptasińska S., Denifl S., Gohlke S. et al. // Angew. Chem. Int. Ed. 2006. V. 45. P. 1893. https://doi.org/10.1002/anie.200503930
- 24. Щукин П.В., Хатымов Р.В. // Масс-спектрометрия. 2013. Т. 10. № 3. С. 158.
- 25. Stokes S.T., Li X., Grubisic A. et al. // J. Chem. Phys. 2007. V. 127. P. 084321.https://doi.org/10.1063/1.2774985
