META-ANALYSIS OF ACID-BASE AND REDOX PROCESSES WITHIN THE MITOCHONDRIAL MATRIX, CYTOPLASM, INTERCELLULAR MEDIUM AND BLOOD BASED ON THE TENSOR APPROACH

Tatevosyan, A.S.; Bunyakin, A.V.; Kastsyuchenko, S.S.; Alekseenko, S.N.; Muronov, A.E.; Katani, Z.O.

doi:10.7868/S3034553725090181

PII

S3034553725090181-1

DOI

10.7868/S3034553725090181

Publication type

Article

Status

Published

Authors

A.S. Tatevosyan

Affiliation: Kuban State Medical University, Ministry of Health of the Russian Federation

A.V. Bunyakin

Affiliation: Kuban State University

S.S. Kastsyuchenko

Occupation: Cleveland Clinic
Affiliation: Anesthesiology Institute

S.N. Alekseenko

Affiliation: Kuban State Medical University, Ministry of Health of the Russian Federation

A.E. Muronov

Affiliation: Kuban State Medical University, Ministry of Health of the Russian Federation

Z.O. Katani

Affiliation: Kuban State Medical University, Ministry of Health of the Russian Federation

Volume/ Edition

Volume 99 / Issue number 9

Pages

1431-1442

Abstract

The most important indicator of homeostasis is the acid-base balance (ABB), which for the last half century in clinical practice has been assessed based on the Boston or Copenhagen schools, or relying on the physicochemical interpretation proposed by P. Stewart, which changed the emphasis from direct pH readings to the generalized state of electrochemical equilibrium of the blood. Today, it is generally recognized that all three approaches to assessing the ABB have weaknesses, and they do not have convincing clinical advantages. Since it has been experimentally established that with metabolic acidosis, 57% of buffering is carried out intracellularly, it is more appropriate to consider the ABB not as a purely isolated blood indicator, but to assess it within the framework of energy metabolism (dissimilation), which is a consequence of oxidation-reduction reactions within the mitochondrial matrix, their intermembrane space and the cell cytoplasm, which can be solved by mathematical modeling. The use of tensor notation for mathematical model equations is not only the adoption of standardization rules, but a far-reaching ideology of the invariance of these equations (preservation during transformations of a certain group). The presented work shows that acid-base and oxidation-reduction homeostasis in mathematical model equations can be interpreted as “play” (variations within established boundaries during transformations of a certain type) for specially formulated tensor invariants.

Keywords

кислотно-основной и окислительно-восстановительный гомеостаз люфт функциональности тензорные инварианты

Date of publication

13.03.2026

Year of publication

2026

Number of purchasers

Views

References

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GOST	Alekseenko S., Bunyakin A., Kastsyuchenko S., Katani Z., Muronov A., Tatevosyan A. META-ANALYSIS OF ACID-BASE AND REDOX PROCESSES WITHIN THE MITOCHONDRIAL MATRIX, CYTOPLASM, INTERCELLULAR MEDIUM AND BLOOD BASED ON THE TENSOR APPROACH // Russian Journal of Physical Chemistry. – 2025. – V. 99. – Issue number 9 C. 1431-1442 . URL: https://physchemras.ru/s3034553725090181-1/?version_id=124987. DOI: 10.7868/S3034553725090181
MLA	Alekseenko, S.N, Bunyakin, A.V, Kastsyuchenko, S.S, Katani, Z.O, Muronov, A.E, Tatevosyan, A.S "META-ANALYSIS OF ACID-BASE AND REDOX PROCESSES WITHIN THE MITOCHONDRIAL MATRIX, CYTOPLASM, INTERCELLULAR MEDIUM AND BLOOD BASED ON THE TENSOR APPROACH." Russian Journal of Physical Chemistry. 99.9 (2025).:1431-1442. DOI: 10.7868/S3034553725090181
APA	Alekseenko S., Bunyakin A., Kastsyuchenko S., Katani Z., Muronov A., Tatevosyan A. (2025). META-ANALYSIS OF ACID-BASE AND REDOX PROCESSES WITHIN THE MITOCHONDRIAL MATRIX, CYTOPLASM, INTERCELLULAR MEDIUM AND BLOOD BASED ON THE TENSOR APPROACH. Russian Journal of Physical Chemistry. vol. 99, no. 9, pp.1431-1442 DOI: 10.7868/S3034553725090181

RAS Chemistry & Material ScienceЖурнал физической химии Russian Journal of Physical Chemistry

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